Orochimaru was a genius!
He had collected a vast number of ninjas with bloodline limits, and over the years, he had extracted sera from these bloodline limits.
Serum could indeed grant the person injected with it the corresponding bloodline limit, but the problem was that this energy was far too tyrannical, and the moment of a successful injection was often the moment of physical collapse.
Orochimaru had died three times because of this, replacing his body three times.
The price paid was also immense.
After several failed experiences, Orochimaru understood that if he wanted to carry out his grand plan, he needed a powerful physical body.
Yet among powerful physical bodies, the Senju and Uzumaki were undoubtedly the top choices in the entire ninja world.
The problem was that,
due to the matters Third Hokage Hiruzen Sarutobi had handled, whether it was the Senju Clan within Konoha Village or the Uzumaki Clan of Whirlpool Country, the direct bloodlines had almost entirely died out.
Naruto Uzumaki had the Nine-Tails inside him, and Orochimaru did not want to touch him.
The other Senju clansman was Tsunade, and Orochimaru was well aware that Tsunade had not awakened the power of her grandfather Hashirama Senju, so there was no need for him to provoke her.
As a result, the only thing he could choose was Hashirama Cells.
When he was basically working for Danzo Shimura, Orochimaru knew just how terrifying the corrosive nature of Hashirama Cells was; once injected into the body and left unchecked, he would be devoured by the Hashirama Cells and turned into a tree.
Fortunately, relying on the Root's resources, he had found a way to keep the Hashirama Cells in check.
That was to use the bloodline limit of the Uchiha Clan.
Orochimaru ultimately discovered that whether he wanted