Arc 21The Ten-Tails and Kaguya
Genitsu revealed himself as the force behind the war, sought to reshape the world with Planet Godzilla, and defeated Kaguya while pursuing the Ōtsutsuki Main Family. The arc ended with Genitsu ordering Orochimaru to summon King Ghidorah.
- Kabuto revealed himself as Hitomi and joined Genitsu, who arrived at the battlefield with Kakashi and Iroha as Naruto and Madara fought.
- Genitsu exposed his role in the crisis, allied with Madara and Nagato, and extracted the Eight-Tails and Nine-Tails to revive the Ten-Tails.
- Isshiki revived and brought a second Ten-Tails, while the Sage of Six Paths gave Sasuke his remaining Six Paths Power and Sasuke revived Naruto.
- Genitsu left for the Pure Land, killed the Sage of Six Paths, shattered the moon, and returned with enough strength to release Planet Godzilla.
- Madara cast Infinite Tsukuyomi, but Genitsu spread his cells across the planet as Planet Godzilla attacked the Divine Trees, and Black Zetsu revived Kaguya from Madara.
- Kaguya fought Genitsu and Isshiki across her dimensions, but Genitsu used Karin to prevent Isshiki from resurrecting through her body.
- Genitsu overwhelmed Kaguya, extracted the eight Tailed Beasts, sealed them, and brought her back to the Shinobi World after destroying Black Zetsu.
- Orochimaru attempted to summon the being he had contacted through Planet Godzilla's injury, and Genitsu ordered him to summon King Ghidorah with the complete chant.