Mousse's conversion of the so-called "meridians and acupoints," which were essentially like an Empirical Formula, into real human bodily systems, organs, and tissues through his immense store of knowledge was undoubtedly more precise and safer than Sea King's original version.
Of course, that safety was only relative. If someone practiced it every day like Huo Lisha, hormonal imbalance would only be a matter of time. Thus, Mousse planned to stop after testing out the methods and effects of stimulating every major gland. After that, he would only treat it as a trump card to use when absolutely necessary.
In any case, Mousse now understood that once Haki had activated the benefits of so-called internal energy on the body, those benefits would remain continuously effective. Further practice would only make him more adept at using Haki to replicate supernatural abilities; it would not affect his rate of growth.
Therefore, the greatest benefit Mousse gained from this research was actually a method for Observation Haki to stimulate the human body's organs—self-hypnosis!
In fact, Sea King Divine Skill's ability to increase muscle strength so dramatically was partly due to this as well. Otherwise, merely stimulating the adrenal glands to secrete hormones, while certainly effective, would have side effects too severe for the human body to endure.
Though the benefits brought by this aspect were not as great as stimulating the glands, it was much safer. It could not be said to have absolutely no side effects, but they were far milder than the consequences of frequently stimulating the glands. It could also, to some extent, unleash one's potential and accelerate growth.
Although Huo Lisha could not explain it clearly, with Mousse's intellect and knowledge, all he needed to know was that Observation Haki could directly affect his thoughts. He could find a way