Hyuga Shinichi knew that although Tobirama Senju disliked the Uchiha, it was because of the wars between their clans in the past.
During his time as the Second Hokage, he had still treated the Uchiha Clan fairly well. He had even entrusted them with managing the Konoha Military Police Force, an important law enforcement agency.
The Konoha Military Police Force was mainly responsible for maintaining public order in the village. This also showed Tobirama Senju's trust in the Uchiha.
At the same time, it let him keep an eye on the Uchiha Clan's every move. Tobirama Senju had studied the clan in depth and understood them well. The risk of them losing control was simply too high.
The Uchiha Clan's love was stronger than anyone else's. Because they loved so deeply, the emotional shock of losing that love gave them power—but also twisted their personalities and made them extreme.
Every Uchiha who awakened the Mangekyō Sharingan trusted only his own judgment. For instance, after seeing the account on the Ancestral Stone Tablet, Uchiha Madara decided that only the Infinite Tsukuyomi could bring true peace.
After witnessing the death of the girl he loved, Uchiha Obito refused to believe it was real. When he learned of Uchiha Madara's Infinite Tsukuyomi plan, he too decided that it was the perfect world.
So nothing in reality mattered anymore. They would all meet again in the world of the Infinite Tsukuyomi, after all. And after traveling the Shinobi World as Uchiha Madara, he became even more convinced that the Infinite Tsukuyomi was the ideal world.
Uchiha Shisui and Uchiha Itachi were both just as single-minded about protecting the village's peace. They wanted to start with the Uchiha Clan, rather than target the village leadership.
Of course, they also knew that the Uchiha Clan could