Chapter Summaries

Itachi received Orochimaru’s potion and instructions for changing his DNA, then injected it and became completely paralyzed. Konan woke to find him motionless with a syringe in his shoulder and, after a confused misunderstanding, resumed keeping watch as Itachi remained unable to explain what was happening.

• Itachi opened Orochimaru’s delivery and read that the potion might let him alter his DNA to match Shisui’s, while learning Danzo possessed Shisui’s other Mangekyo Sharingan.
• Itachi memorized Orochimaru’s healing technique, burned the letter, and injected the potion into his arm.
• The potion left Itachi unable to move or speak as his genes and DNA rapidly dissolved and restructured.
• Konan woke in the cold and nearly used Explosive Tags to relight the fire before spotting an ember.
• Konan mistook Itachi’s exposed shoulder and syringe for signs of an ambush, then realized he might be incapacitated and left the syringe in place.

Itachi suffered severe effects after injecting Orochimaru’s serum, leaving him unable to move as his cells fought each other. Konan brought him to Hidden Rain Village’s hospital, where the physicians suspected a Bloodline Disease but could not explain his condition.

• Itachi wondered whether Orochimaru had hidden the serum’s dangerous side effects from him, while Orochimaru anticipated that Itachi would seek him out.
• Konan kept Itachi by the fire through the night, but he remained motionless and grew increasingly feverish and pale.
• Konan carried Itachi back to Hidden Rain Village after his vision failed and he lost control of his body.
• The hospital examined Itachi and found that two factions of his own cells were fighting within him.
• A physician told Konan that Itachi might have a Bloodline Disease, leaving the hospital unable to identify the cause.

Itachi lay incapacitated with Bloodline Disease until Obito extracted the Three-Tails and tried to take his Sharingan. Itachi awakened, destroyed one eye to distract Obito, and escaped with the Reverse Summoning Technique.

• Konan told Pain that Itachi might have Bloodline Disease and that the doctors had no effective treatment.
• Pain removed Itachi's ring and left to find a replacement, while Kisame visited and took an orange.
• Obito extracted the Three-Tails from Itachi and implanted Itachi's right Mangekyo Sharingan in his own eye socket.
• Obito tried to take Itachi's left eye, but Itachi awakened and offered to remove it himself.
• Itachi crushed the Mangekyo Sharingan he had removed and used the Reverse Summoning Technique to disappear.

After reaching Ryuchi Cave, Itachi replaced one damaged eye with the Mangekyo Sharingan from his crow and resolved to make Obito pay for taking his other eye. The White Snake Sage summoned him and offered to help, though she could not immediately improve his condition.

• Itachi removed the Mangekyo Sharingan from his crow and used a healing technique to connect it to his eye socket.
• Itachi continued through Ryuchi Cave with the now-blind crow on his shoulder and decided to seek Sage Jutsu.
• Itachi recalled how Obito had taken one eye and forced him to destroy the other, then vowed to make things difficult for him.
• Ichikishimahime arrived and escorted Itachi to the White Snake Sage's temple.
• The White Snake Sage welcomed Itachi, said he would recover soon, and asked whether he needed help.

Itachi asked the White Snake Sage to teach him Sage Jutsu, but she told him to rest and replace his other eye first. Ichikishimahime took him to a guest room, where she brought fruit for him and grain for his crow after his request for meat.

• Itachi asked the White Snake Sage to teach him Sage Jutsu, and she advised him to recover and replace his other eye first.
• The White Snake Sage told Ichikishimahime to take Itachi to a guest room and warned her not to neglect him.
• Ichikishimahime led Itachi to the room, where he flirted with her and said he wanted meat to eat.
• Ichikishimahime brought fruit for Itachi and grain for his crow, then teased the crow while feeding it.
• Itachi remarked that birds could eat fruit too, irritating Ichikishimahime as she insisted the food had been prepared for the crow.

Konan discovered that Itachi had vanished from the Hidden Rain Village hospital, and Pain suspected someone had helped him escape. After recovering in Ryuchi Cave, Itachi prepared to leave with his crow, reassuring Ichikishimahime that they were comrades and that he would return to practice Sage Jutsu.

• Konan found Itachi, his bedding, and his nutrient medicine missing, then reported his disappearance to Pain.
• Pain suspected a masked figure was involved but told Konan to return to her work.
• After half a month in Ryuchi Cave, Itachi's body had recovered and his genes, DNA, and blood had been replaced.
• Ichikishimahime brought Itachi food, and he told her he planned to leave with the crow and find it a new eye.
• Ichikishimahime asked whether they were companions, and Itachi assured her they were comrades-in-arms before promising he would return to practice Sage Jutsu.

Itachi left Ryuchi Cave after saying goodbye to Ichikishimahime and traveled to meet Orochimaru. He told Orochimaru that an organization had gouged out his eye while he was weakened, and Orochimaru promised to help replicate a Mangekyo Sharingan.

• Ichikishimahime urged Itachi to take care of himself and Little White, and Itachi named the crow before leaving Ryuchi Cave.
• Tagorihime and Tagitsuhime teased Ichikishimahime after Itachi departed.
• Itachi traveled for two days, following a snake that tracked Orochimaru's scent to his underground residence.
• Orochimaru welcomed Itachi and reacted angrily to his damaged eye.
• Itachi explained that the organization had taken advantage of his weakened condition, and Orochimaru admitted he had withheld the side effects to expose the organization's true nature.
• Orochimaru reassured Itachi that he would soon help him replicate a Mangekyo Sharingan.

Itachi asked Orochimaru why Shisui's Mangekyo Sharingan had not become an Eternal Mangekyo Sharingan, and Orochimaru suggested that he might need both eyes. Over wine, Orochimaru exposed that Itachi had given him someone else's Mangekyo cells, but left their identity unknown.

• Itachi asked Orochimaru why Shisui's eye had not transformed into an Eternal Mangekyo Sharingan.
• Orochimaru suggested that Itachi might need both eyes and said the other eye was in Danzo's eye socket.
• Itachi and Orochimaru drank the same wine they had shared when they first met and discussed business, and Orochimaru teased Itachi about forgetting to pay.
• Orochimaru said his Mangekyo replication research was progressing slowly and accused Itachi of giving him cells that were not his own.
• Itachi admitted he had held something back and invited Orochimaru to guess whose eye the cells came from.

Itachi tested Orochimaru by pretending to get drunk, then woke to find Orochimaru had replaced one of Little White’s eyes. Over breakfast, Orochimaru proposed infiltrating Danzo’s base and killing him, leaving Itachi to warn him that Danzo possessed Shisui’s Mangekyo Sharingan.

• Itachi pretended to get drunk at dinner with Orochimaru, then secretly stayed alert after being taken to a guest room.
• Orochimaru visited his laboratory during the night to look for a suitable eye for Itachi.
• Itachi woke in the morning and saw that Orochimaru had replaced one of Little White’s eyes.
• Little White tried to offer its new eye to Itachi, but Itachi told it to keep the eye and watch over the other half of the world.
• Orochimaru asked Itachi to help create a village with him, and Itachi said he still needed to return to Konoha and see his brother.
• Orochimaru proposed infiltrating Danzo’s base to kill him, and Itachi cautioned that Danzo possessed Shisui’s Mangekyo Sharingan.

Itachi questioned Orochimaru about Danzo and learned that Danzo had a Sharingan-filled arm strengthened with Hashirama Cells, making him capable of using Izanagi. Itachi settled on using his own Kotoamatsukami against Danzo and told Orochimaru to provide support.

• Itachi asked Orochimaru what he knew about Danzo, and Orochimaru revealed Danzo's Mangekyo Sharingan, Hashirama Cells, and armful of Three-Tomoe Sharingan.
• Orochimaru explained that he had created the arm while researching Wood Release, but his experiment had produced only a weak user of the technique.
• Itachi explained that Danzo could use Izanagi to turn injuries and death into dreams, while Orochimaru worried that Danzo's many Sharingan would make him difficult to defeat.
• Itachi considered Danzo's chakra reserves and Kotoamatsukami, then decided to use his own Kotoamatsukami directly against him.
• Itachi told Orochimaru that he had a plan and asked him to provide support.