As the finest Medical Ninja in the Shinobi World, how could Tsunade not be curious about kekkei genkai disease?
So, after learning about Uchiha Itachi's condition, she pestered Shin Uchiha for quite some time before finally getting a chance to examine Itachi.
She discovered that his kekkei genkai disease was actually a genetic disorder. For some unknown reason, Uchiha Itachi's genes were slowly breaking down.
Even with Tsunade's unparalleled medical expertise, she could only alleviate his condition, not cure it.
And as time passed, Uchiha Itachi neglected his health, often forgetting to take the medicine Tsunade had prepared for him. His condition soon spiraled out of control.
After answering Kushina's question, Tsunade turned her attention back to the distant battle.
But as time passed, her brow furrowed deeper and deeper, as though she had noticed something wrong. Finally, she could no longer hold back and asked hesitantly,
"Shin, why do I get the feeling that something's off about Uchiha Itachi today?"
"Something's off? What's wrong with Itachi?"
At Shin's question, Tsunade observed the fight carefully again before continuing,
"I've only met Uchiha Itachi a few times, but I've studied his files extensively. From what I've seen, Itachi is an incredibly intelligent fighter. He doesn't need to clash head-on like this in battle. He can quickly identify his enemies' weaknesses and defeat them at minimal cost, without putting much strain on himself."
At that, Tsunade pointed at Uchiha Itachi in the distance.
"But look at him now. He's using the most foolish way of fighting there is.
With his body in its current condition, fighting this intensely is practically asking to die."
At Tsunade's words, Shin Uchiha nodded and sighed.
"Tsunade, you're right. He really is asking to die."
Shin Uchiha paused, then rephrased his words.
"Or rather, he's seeking death."