"The key lies in pH value. The pH value of the microenvironment near tumor cells differs from that of normal cells. Our team's idea is to create an artificial bacterium that can use changes in pH to identify tumor cells and precisely deliver drugs to them!"
"What's its specific structure?" Song He asked.
"The shell is a double-shielded layer of Targeted Polysaccharide, with special pH-responsive Chemical Bonds embedded in it. It's essentially a switch that activates automatically upon reaching the vicinity of tumor cells." Ji Tianhe said, "It's still in development. No drugs have been loaded inside yet. We're using Dendritic Polypeptide, which has some tumor-lysing effects, and embedding Gold Nanorods inside."
"Are the polypeptides bound to the Gold Nanorods through Ligand Exchange?" Song He asked.
"Yes, but the current binding rate isn't high. We're looking for a solution." Ji Tianhe said.
"There's already a solution." Song He said.
"Huh?" Ji Tianhe was stunned.
"Xiang Province University has an expert in this field, Professor Xu Xianghui. He once developed something very similar—an artificial bacterium designed to tackle cancer as well." Song He pondered for a moment. "If I remember correctly, his method involved DNA Methylation to reverse the charge and improve the binding success rate. You could give it a try."
"Great!" Joy flashed across Ji Tianhe's face. As an insider, he could instinctively tell that the method would probably work.
Then he felt somewhat ashamed. Since someone had already attempted something similar, why hadn't he found it while gathering information? Their leader hadn't worked in this area, so how could he have such a vast store of knowledge ready at his fingertips?
Clearly, he still had a long way to go. Ji Tianhe frowned slightly.
"This one is interesting." Song He shook the data sheet in his hand.
Ji