The greatest impact Uzushio Village's destruction had on Konoha was probably the Nine-Tails Incident that followed.
If Uzushio Village had not been destroyed, then when Kushina gave birth, considering that a Jinchuriki's ability to suppress the Nine-Tails would drop to its lowest point, the Uzumaki Clan's patriarch would certainly have personally rushed to Konoha to oversee things.
And if there had been an Uzumaki patriarch with Kage-level strength who specialized in Sealing Jutsu present that night, working together with the Fourth Hokage's "Flying Thunder God Technique," it would not have been so easy for Obito to trigger the Nine-Tails Incident on his own.
For all anyone knew, even Obito himself might have ended up falling there.
After all, if he were truly restrained by a Sealing Jutsu like "Adamantine Sealing Chains," capable of suppressing Tailed Beast-level chakra, Obito probably would not even have been able to use "Kamui" to escape.
However, reality did not have so many what-ifs.
The fundamental cause of the Nine-Tails Incident was actually the First Hokage's death, which caused "Wood Release" to vanish from Konoha, and the loss of the Uzumaki Clan's support after Uzushio Village's destruction. In the end, this caused the Hokage faction's ability to control Tailed Beasts to plummet off a cliff.
That was the true root cause of the Nine-Tails Incident!
From this, it seemed that a black hand had been secretly weakening Konoha's strength all along.
For instance, the inexplicable rebellion by the Kinkaku and Ginkaku brothers during the signing of the armistice agreement not only cost Kumogakure the Second Raikage, but also trapped the Second Hokage, who had gone to sign the agreement, in an encirclement. In the end, he died far from home while protecting his disciples.
Judging from the situation at the time, Kumogakure still had a powerhouse