Thirteen: Getting There First
The story of how Sherry was infected with the Bio-Virus began with her father, William Birkin.
In the Resident Evil series, both of Sherry's parents were senior researchers at the Umbrella Corporation.
In the Resident Evil movies, Sherry's father, William, had initially researched the T-Virus to cure Sherry's congenital illness. Sherry had already been inoculated with the T-Virus when she was very young.
Her congenital illness had improved as a result, and it had not continued to worsen. She simply needed to use the relevant injections regularly.
After Alice found Sherry, Sherry had also admitted in person that she was infected with the T-Virus.
Of course, at this stage, it was never clearly stated whether Sherry had been infected a second time before Alice found her, or whether she still needed to keep taking the T-Virus Vaccine. There were no later plot details about Sherry being infected with the T-Virus, either.
In the Resident Evil games, the situation with Sherry's father, William, was much more complicated. He was clearly a more senior researcher than his movie counterpart, probably the highest-ranking person in charge on the Raccoon City side.
William's original reason for researching the Bio-Virus was not to cure his daughter, but to gain the corresponding power and status.
Before he was mistakenly killed by a special operations squad sent by Umbrella headquarters amid internal conflicts over interests within the Umbrella Corporation, he injected himself with the G-Virus he had developed and turned into a terrifying Monster.
The reason the Resident Evil outbreak in Raccoon City fully erupted in the game was that William, transformed into a Monster, went on a rampage at the Biohazard Sewage Treatment Plant and crushed several T-Virus Reagents. This caused the T-Virus to flow into Raccoon City's sewers, resulting in a large-scale infection.
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