Replication
The capsule-shaped drug was developed and marketed by Eli Lilly and Company in the United States. Its generic name in the United States is called Le Luo Xian Fen, and its brand name is Ivy.
This medicine is usually called Le Luo Xian Fen capsules in China. A box contains twelve capsules and costs 9,600 RMB. Ou Ye took one capsule daily before becoming pregnant.
The tablet-shaped drug was developed and marketed by Novartis and is known domestically as Condo Caren.
Speaking of this Swiss pharmaceutical giant, their famous anti-leukemia drug Gleevec was once extremely expensive, known as an exorbitantly priced drug, and caused quite a stir.
The Condo Caren that Ou Ye takes isn't cheap either; one bottle costs 12,000 RMB, and she takes two bottles a month.
The greatest motivation for every patient is to stay alive with medication, clinging to a sliver of hope that they will survive until new medical technologies emerge.
However, many patients cannot afford the exorbitant prices of medicines. Medical insurance can reimburse a portion of the costs, but it cannot cover every single drug in the world.
It may be expensive, but the key is to address the root cause.
Shen Qi operated chemical experimental instruments to conduct professional analysis of Le Luo Xian Fen and Condo Caren. This is a comprehensive operation that requires mastery of various chemical knowledge and practical skills, including organic, inorganic, and analytical chemistry.
Shen Qi discovered through experiments that Le Luo Xian Fen is actually a benzothiafen compound, costing 800 yuan per pill, and once swallowed, it's gone—it's damn expensive.
Compared to men, women have stronger immune systems, which allows them to resist more infections.
However, due to the role of estrogen and progesterone in the immune response, women are also more susceptible to Autoimmune Disease.
The main function of Le Luo Xian Fen is to regulate estrogen, and it has a good effect on female patients with Autoimmune Disease.
The chemical nature of Condo Caren is that of an oxazolidinone compound, which is said to be the best drug in the world for treating Morris Anemia.
From a scientist's perspective, so-called exorbitantly priced drugs are not so mysterious; they are essentially chemical products obtained through chemical reactions.
"Chemistry, upgraded to level 12."
"Level up my Biology class to level 12 as well."
Sizzle!
Tremors!
Shen Qi was dizzy for a few seconds, then returned to normal, with both his Chemistry and Biology scores rising to level 12.
Level 11 is the standard master level set by the system. In Chemistry and Biology, even with excessive academic effort, the highest level that can be achieved is the advanced master level of 12.
Level 13 is the top-tier Master level, and certain conditions must be met to upgrade from Level 12 (High-end) to Level 13 (Top-tier).
The requirements for advancing from Chemistry Level 12 to Level 13 are:
1. 4 million academic points or experience points;
2. Obtain any of the following Chemistry Prize to demonstrate the host's mastery level.
The system generated a list that included over a dozen internationally renowned Chemistry Prize, such as the Nobel Chemistry Prize, the Wolf Prize in Chemistry Wilsie Prize in Chemistry, the International Carbohydrate Award, and the International Catalysis Award Prize.
The conditions for a creature to advance from level 12 to level 13 are:
1. 4 million academic points or experience points;
2. Train at least five outstanding PhDs in biology.
"...30,012,781 Academic Points remaining. Please confirm."
The king of Science and Engineering, chemistry, and physiology has been born today.
Apart from Shen Qi, there should be no other person in the world today who has reached level 14 in mathematics and physics, and level 12 in chemistry and biology.
For chemistry and biology to continue to advance, Shen Qi needs to achieve academic research results in the real world or cultivate outstanding young talents.
It's very difficult for someone from the Class of 2012 to win the Nobel Chemistry Prize, Shen Qi could try for other Chemistry Prize.
Mentoring five outstanding PhD students in the field of biology takes a considerable amount of time, effort, and emotion, and Shen Qi first needs to obtain the qualification of Doctoral Supervisor in biology.
I've passed both Math and Physics exams at level 14, and Chemistry and Biology exams at level 12. I'll make do with this for now.
Science and Engineering, and biology are not entirely independent. Mathematics points the way, physics ignites the spark, chemistry interweaves with each other, and biology follows closely behind.
When a scientist's understanding of Science and Engineering, and biology reaches a certain level, they can integrate these skills and establish their own school of thought. This depends on the scientist's ability to perceive and synthesize information.
In Laboratory 401 of the Center, Shen Qi is conducting a chemical experiment all by himself.
"Arylation of boric acid 43 by Suzuki Coupling Reaction".
"Benzothiafen 13 was obtained in 81% yield."
"The Ionic Liquid (N-methyl,4-butylimidazolium tetrafluoroborate) was recovered and used for the Friedel-Klatz reaction... cough cough!"
During the Friedel-Clatz reaction, a large amount of pale red mist is generated in the reactor vessel; it is acidic and has a pungent odor.
Even with a mask on, Shen Qi couldn't help coughing as he flipped through chemistry literature.
The literature states that the Friedel-Klatz reaction is conducted in this way, requiring experimenters to wear full protective gear and maintain ventilation in the laboratory.
The Friedel-Clatz reaction is named after these two chemists who first discovered and reported it.
There are too many named reactions in organic synthesis; it's very difficult to memorize all of them, along with their principles and phenomena.
Shen Qi continued his chemical synthesis experiments.
"28c with a complete Le Luo Xian Fen skeleton was obtained with a yield of 79%."
"Introducing a 2-hydroxyethylpiperidine side chain via a copper-catalyzed coupling reaction."
This reaction step again utilizes Ionic Liquid (N-methyl,4-butylimidazolium tetrafluoroborate).
Sizzle!
A second wave of acidic, pungent, pale red mist swept through the air.
Shen Qi was used to it and had developed a psychological resistance to it.
Finally, in Lewis Acid Ionic Liquid (Trimethylammonium trichloride aluminum salt), Shen Qi obtained Le Luo Xian Fen in a yield of 43%.
Le Luo Xian Fen capsules sell for 9600 yuan per box, or 800 yuan per capsule.
By studying the instructions for Le Luo Xian Fen capsules and relevant chemical literature, and using the actual Le Luo Xian Fen capsules as a sample reference, Shen Qi synthesized Le Luo Xian Fen in his 401 experiment.
Theoretically, that's correct, assuming Shen Qi's experimental procedures were correct.
Eli Lilly and Company certainly wouldn't tell Shen Qi the specific technical details of Le Luo Xian Fen preparation. Shen Qi reverse-engineered the process and obtained Le Luo Xian Fen.
Whether Shen Qi's version of Le Luo Xian Fen has the same therapeutic effect as the Le Luo Xian Fen version needs further verification.
Even if Shen Qi successfully replicates Le Luo Xian Fen, he cannot sell it because Eli Lilly and Company has already applied for a global patent for the drug.
There should be a few chemists in the world with Shen Qi's ability to reverse-engineer and his operational skills.
The Gleevec produced in India is basically no different from the Gleevec. It turns out that the cheaper Indian Gleevec can also save leukemia patients. There must be chemical experts among the people of India.
"Le Luo Xian Fen, is it really effective?" Shen Qi examined the Le Luo Xian Fen he had made himself; his wife had been taking this medicine for many years.
Verifying the toxicological, pharmacological, pharmacokinetic, and metabolic properties of the self-made version of Le Luo Xian Fen was very important to Shen Qi.
If Shen Qi successfully synthesizes the drug that Ou Ye has been taking in the laboratory, it will give Shen Qi great confidence. Perhaps one day, he will be able to synthesize a new drug with even better efficacy.
According to Eli Lilly and Company, during the development of Le Luo Xian Fen, they conducted pharmacological and toxicological experiments on mice and Le Luo Xian Fen to verify its safety, which enabled it to obtain FDA (Food and Drug Administration) certification and market sales authorization.
"Monkeys? Where can we get monkeys? Monkeys are all nationally protected animals." Shen Qi fell into deep thought. White mice are easy to obtain, but primates for animal experiments are not so easy to get. He would have to ask the School of Medicine or the School of Life Chinese Academy of Sciences for help.