Not as Good as Going Back to the Dorm to Sleep
The research findings on C01C, a benzothiazinone compound, have been published in the Journal of the Journal of the American Chemical Society.
Shen Qi's Chemistry group has published two papers in the Journal of the American Chemical Society, attracting attention within the industry.
At this stage, C01C can only be considered a new compound and cannot yet be called a pharmaceutical product.
Only after completing animal experiments and achieving satisfactory results would C01C's patent application as a glycogen synthase kinase-3β inhibitor be more valuable.
Animal testing was conducted by Ou Beiqi Pharmaceutical, and the patent for C01C was sold to Ou Beiqi Pharmaceutical.
Developing an original drug is not easy; even after passing animal experiments, there are still several phases of clinical trials.
Phase I clinical trials primarily test whether a new drug has toxicity or other harmful effects on healthy individuals. This stage typically involves dozens of healthy volunteers, and the cost can be kept within 10 million RMB.
Phase II clinical trials primarily test the efficacy of a new drug. This stage requires the cooperation of several hundred patients, and the cost will soar to over 100 million RMB.
Following this is Phase III clinical trials to determine the optimal dosage of the new drug. After the drug is marketed, the applicant conducts application research, followed by Phase IV clinical trials to examine the drug's efficacy and adverse reactions under conditions of widespread use. This phase may involve more than 10,000 patients and cost hundreds of millions of RMB.
Before an original drug has even made any money, hundreds of millions of yuan have already been poured into it.
Moreover, even with a large sum of money invested, failure is still possible.
From animal experiments to several phases of clinical trials, if any link goes wrong and the compound is found to be ineffective or harmful, the entire development project has to be scrapped and started over. The development team must continuously improve the properties of the compound in various aspects to meet the relevant standards of the countries where it will be marketed.
Shen Qi to sell the C01C patent, but someone has to be willing to buy it first.
Buying a patent for a new compound isn't expensive, but the subsequent research and development, and testing, are far too costly.
Old Shen's Ou Beiqi Pharmaceutical is fearless; this pharmaceutical factory was originally bought by Old Shen for Shen Qi to play with.
However, if things go wrong, Old Shen's fortune accumulated over twenty years in business will be gone forever, and Shen Qi and Ou Ye's 100 million and Shen Qi's mother-in-law's 100 million will also be lost.
"Any attempt to gain benefits, strive for honor, or satisfy some personal desire carries risks. For example, Xiao Wu, if you follow me to pursue your doctorate, and for the first two years you don't do research projects but become a tutor, that's a risk," Shen Qi said to Wu Shangfeng, a doctoral student in mathematics.
The publication of the C01C paper brought Shen Qi over 400,000 academic points. Including his previous savings, Shen Qi now has 520,000 academic points.
A more effective way to mitigate risks is to improve physical fitness. Shen Qi used 400,000 academic points to upgrade his physical education level to 8.
"What business isn't risky these days? My aunt runs a stall selling jianbing guozi (Chinese crepes), works hard from dawn till dusk for a year, and still lost more than 10,000 yuan," Wu Shangfeng said rather calmly.
"No business is easy these days," Shen Qi said sympathetically to Wu Shangfeng's aunt, then asked, "How's the pilot program for tutoring students going?"
"It's the end of the semester, business is booming... Oh dear, it's time, I have to go." Wu Shangfeng picked up the documents, looking like he was in a hurry to leave.
"Let's go together, I'll go take a look too." Shen Qi walked with Wu Shangfeng.
The two arrived at a large classroom in the teaching building. Wu Shangfeng entered through the front door, while Shen Qi secretly observed from outside the back door.
The students in the classroom are all first-year students from the School of Mathematics. After this final exam, they will enter their second year.
First-year students in the School of Mathematical Sciences study three core courses: Advanced Algebra, Mathematical Analysis, and Analytic Geometry. Shen Qi applied for 12 hours of undergraduate teaching assignments this semester, with 4 hours allocated to each of Advanced Algebra, Mathematical Analysis, and Analytic Geometry. The remaining hours will be taught by lecturers.
After classroom teaching, Wu Shangfeng regularly organizes tutoring sessions to answer the questions of first-year students on Advanced Algebra, mathematical analysis, and Analytic Geometry.
Wu Shangfeng is quite well-rounded; he managed to pass all three basic math courses on his own.
It is possible for a doctoral student to be in charge of tutoring multiple courses for undergraduate students.
At the graduate level, as the courses become increasingly specialized, only all-around mathematicians like Shen Qi can tutor Mathematical Research.
Wu Shangfeng handles tutoring undergraduate students with ease.
"Next, I will analyze a problem in Advanced Algebra, which is quite representative." Wu Shangfeng switched to the PPT, and an Advanced Algebra problem involving matrix operations was displayed on the screen.
Final exams are just around the corner, and the first-year students are listening attentively to Wu Shangfeng's explanation of the problems. They know that Wu Shangfeng is the only mathematics doctoral student that Shen Qi has recruited in China.
Old Wu lectured with great enthusiasm, and the students listened with equal enthusiasm, creating an atmosphere reminiscent of a senior high school class in the university classroom.
Shen Qi's idea is to start a pilot program of tutoring classes with this year's first-year students in the School of Mathematical Sciences.
Wu Shangfeng's two-year tenure as a tutor has come to an end, and this year's freshmen will be completing their junior year.
Shen Qi eagerly awaits to see what changes will occur in the senior students who have received the tutoring program.
Shen Qi, who was secretly observing from outside the back door, discovered that the tutoring class was quite effective.
The first-year students in the School of Mathematical Sciences are highly motivated to learn, especially since final exams are approaching. During this special period, students are bound to be enthusiastic about their studies.
The students were all listening to the lecture and taking notes, except for one girl in the last row who was sleeping on her desk.
Shen Qi crouched down and slipped into the back row of the classroom through the back door without making a sound.
Shen Qi gently sat down next to the sleeping girl, patted her shoulder, and whispered, "Wake up, classmate."
The girl didn't move; she was fast asleep.
Shen Qi swung his fist and punched the girl, which woke her up.
The girl's arm remained draped over the desk. She turned to look at Shen Qi and said unhappily, "What are you doing... Wait, it's you? Is it you, Professor Shen?"
Shen Qi said, "Hey, if you want to sleep, why don't you go back to your dorm?"
The girl looked at the screen in front of her, then turned to Shen Qi and said, "The questions Old Wu was explaining were too easy; I fell asleep while listening to him."
So matter-of-fact, so self-righteous, Shen Qi couldn't help but glance at the girl a few more times. The girl had a narrow forehead, high cheekbones, a thin nose, deep-set eyes, and a prominent horizontal line on her face.
Women with this kind of three-dimensional, layered facial structure may appear impressive on the surface, but they are not actually that impressive.
Shen Qi smiled, casually took the girl's notebook and pen, quickly wrote a problem in the notebook, and then returned the notebook to the girl.
The girl was initially surprised, but quickly regained her composure. She stared intently at the math problem Shen Qi had given her, lost in thought.