Everyone and Their Own
In the early 21st century, more than a dozen academicians jointly proposed upgrading BEPC to BEPC-II to better conduct High Energy Physics research in China.
In 2009, BEPC-II was upgraded and began operation.
However, in the field of High Energy Physics, hardware upgrades can never keep up with the advanced ideas of physicists.
Playing with SLR cameras can ruin your life; studying High Energy Physics can ruin three generations.
Even the wealthiest tycoons who spend money on High Energy Physics will soon find themselves back to square one.
The lofty aspirations of High Energy Physics must be achieved with the support of the nation.
BEPC-II was under the jurisdiction of the Chinese Academy of Sciences, and Shen Qi and Dean Cao's ideas for BEPC-III naturally had to be approved by Dean Bai first.
Dean Bai was away on a business trip these past few days, so Shen Qi and Dean Cao came to scout out the location first.
Director Hu seemed quite surprised upon hearing Shen Qi's vision for the upgrade.
"The construction of China Super Collider is about to begin. Is it still necessary for us to upgrade BEPC-II?" Director Hu's meaning was that BEPC-II should be used as is for now, and it will be fine once China Super Collider is completed.
China Super Collider is a more energy-efficient device than the European Large Collider, with a total investment budget of 100 billion RMB. It will be located in North China, and the conceptual design has been completed. The construction period is expected to be ten years.
Shen Qi and Dean Cao were certainly aware of the China Super Collider project. Shen Qi said, "Some people say construction on the China Super Collider start this year, some say next year, and some even say why build this thing? It's a waste of money. Even if construction starts this year, it won't be operational for another ten years."
Dean Cao: "I strongly support the China Super Collider project. I participated in the initial research work of this project. But Old Hu, if we wait another ten years, we'll both be too old. As for the upgrade of BEPC, I think it's necessary. Within ten years, BEPC will still be our mainstay. After ten years, BEPC can still be used for teaching."
Old Hu remained noncommittal. "This is a huge matter. Let's wait until Dean Bai returns before discussing it."
A few days later, Dean Bai returned from his business trip.
Dean Bai is a hardware expert. He calculated that upgrading BEPC-II to BEPC-III would require at least 3 billion RMB in funding, and the upgrade cycle would take no less than 3 years, with many accessories needing to be redeveloped.
"3 billion yuan over 3 years, is that really necessary, Shen Qi?" Dean Bai asked.
Shen Qi opened his laptop and pulled up a file. "I've done some preliminary calculations these past few days, and around 1.5 billion should be enough. The upgrade can be completed within a year and a half. Dean Bai, you and I both know that the China Super Collider project is definitely going to happen, but when it will be completed is unknown. For a long time to come, our High Energy Physics research in China will still have to rely on BEPC. I believe that upgrading BEPC is necessary."
Dean Bai carefully examined Shen Qi's calculation plan. After a long while, Dean Bai said, "Shen Qi, you've really gone to great lengths for our Chinese Academy of Sciences. Why don't you become the next dean?"
"Dean Bai is joking," Shen Qi waved his hand and laughed.
Ultimately, Dean Bai decided that the upgrade plan for the Capital Electron-Positron Collider project needed to be submitted to the national government, which would then decide whether to invest human, material, and financial resources in the upgrade.
The work of reporting to the state was carried out by the Chinese Academy of Sciences, while Shen Qi released the improved physics framework, which clearly defined the four the Hidden and the Physics of Tomorrow.
While the national BEPC-III project was underway, Shen Qi received the latest news from Ou Beiqi Pharmaceutical.
Regarding the compound C01C-2, its plasma half-life in rats, dogs, and macaques is 1.7–4.9 h, and its oral bioavailability is 68%–100%.
In these experimental animals, CO1C-2 is primarily cleared by the kidneys in its intact parent drug form, and can also be partially cleared through bile excretion and physiological metabolism.
In other words, the animal experiments for C01C-2 have been successfully completed, and it can now proceed to the clinical trial stage.
The positioning of C01C-2 is now very clear: it is a chemical drug for treating diabetes.
Phase I Clinical Trial primarily investigate human tolerance to new drugs and propose preliminary, safe, and effective dosing regimens to guide the next phase of clinical trials.
Phase I Clinical Trial typically involve 10 to 30 participants, primarily healthy volunteers, but may also include some patients.
Most pharmaceutical companies entrust qualified institutions to conduct clinical trials, Ou Beiqi Pharmaceutical also plans to do so, entrusting an institution in Nangang City to conduct Phase I clinical trials for C01C-2.
The above information was conveyed by Old Shen to Shen Qi.
Shen Qi naturally had no objection; let's do it.
When Shen Nuo Fei turned two years old, C01C-2 entered Phase I clinical trials.
Shen Qi is paying attention to the clinical trial performance of C01C-2 and the project approval of BEPC-III. He is quite busy, but he also has to find time to keep an eye on the Mathematical Grand Unification Project, as well as his wife and beloved daughter.
Ou Ye's health condition is in a stable but unstable state. She has been taking medication without stopping, but her condition remains the same, and the root cause cannot be cured.
For a couple like Shen Qi and Ou Ye, who have both status and savings, one child is a bit too few; it would be best to have as many children as possible.
The couple already has a daughter; if they had a son, they would have both a son and a daughter, which would be perfect.
Shen Qi another son, and so did Ou Ye.
When Ou Ye and Shen Nuo Fei met, Ou Yesheng was 28 years old. She is 30 years old this year, which is not too old.
Under normal circumstances, it is not a problem for a 30-year-old woman to have another child.
But no matter how much Shen Qi and Ou Ye tried, they just couldn't get Erbao to have the desired result.
What if I can't get it to work?
Then let's go all out!
The problem is, despite Shen Qi and Ou Ye's best efforts, there was still no good news.
Instead, it took a toll on Ou Ye's body.
"Take a break, take a break." Shen Qi was drenched in sweat; he had already done his best.
"My health is still holding me back," Ou Ye said guiltily, then added, "That C01C-2 you have is for treating diabetes."
Shen Qi sighed, "Well, theoretically speaking, glycogen synthase kinase-3β is a target associated with many diseases, including diabetes, Alzheimer's disease, cancer, and immune diseases. I initially wanted to focus on immune diseases, but as you know, chemistry is a very complex field. As I worked on it, I ended up making C01C-2 into a drug for treating diabetes. Perhaps my expertise in chemistry and biology isn't enough to achieve a precise target. I'm sorry, my wife."
"It's alright. If you can cure diabetes, that would be a great deed." After all, Ou Ye was a researcher, and she could distinguish between the greater good and personal interests.
Shen Qi felt terrible. Even if I could heal the whole world, it would be too heartbreaking if I couldn't save my wife.
"Honey, don't worry. In the process of researching C01C-2, I've also learned some new things. In the future, there will be C01C-3, C01C-4, and so on, until your illness is cured."