Yes, I Want to Know

The valid nomination period for the Nobel Prize is from September to January 31 of the following year.

Qualified recommenders are former Nobel laureates, Nobel Prize Committee, or university professors specially designated by the Nobel Prize Committee.

Most of the surviving Nobel Prize in Physics laureates recommended that Shen Qi be selected as the next Nobel Prize in Physics laureate.

The Nobel Prize Committee also voted for Shen Qi; in any case, Academician Stinga voted for him.

Throughout Nobel's history, some have refused the Literature Prize, but no one has ever refused a Nobel Prize in the sciences.

As a two-time Nobel Prize in Physics laureate, Shen Qi prefers to leave the opportunity to others, and his attitude is. "Let nature take its course."

Academician Stinga came partly to persuade Shen Qi to accept the award, and partly for academic exchange.

"I deeply regret that I didn't go to the LHC last year to participate in the great experiment on the Black Hole Information Paradox, but I read Professor Shen's paper on the experiment in its entirety. The last LHC experiment proved that information does not disappear after entering a black hole. But I have a question: after the information is processed by the Wave Function and enters the black hole, where does it go, and in what specific form does it exist?"

"Karl, do you really want to know?" Shen Qi smiled, his calm demeanor tinged with mystery.

"There's a Chinese proverb: 'If I hear the Way in the morning, I can die content in the evening.' Yes, I want to know."

"Your Chinese is quite good, come with me."

Shen Qi then displayed a previously unpublished document.

Academician Stinga was stunned after reading it.

"Oh, it's a pity this is just a simulation model... If only it were real..." Academician Stinga murmured to himself. He genuinely felt that Shen Qi going to accept the Nobel Prize was a gesture of respect to the Nobel Prize.

Afterwards, Shen Qi arranged for Sha Dongdong to take Academician Stinga out for hot pot to calm his nerves.

Next, Shen Qi received Academician Alexander Nelson.

Academician Nelson is a Medicinal Chemist, and he and his assistants are very interested in the LPJK1 project at the Shen Qi Research Center.

The LPJK1 project is currently undergoing animal testing, and the number of candidate Active compound is constantly decreasing. With only 5 active compounds remaining, major pharmaceutical companies, including GLK, have been inquiring about the relevant situation of Shen Qi Research Center.

Not only pharmaceutical companies, but also some academic institutions are paying attention to the latest developments of Shen Qi's laboratory. For example, the group of scholars, including Academician Nilsson of the Swedish Royal Academy of Sciences.

"Professor Shen, may we visit your medicinal chemistry lab?" Academician Nelson asked.

"Of course." Shen Qi led his Swedish friend into the laboratory.

The central Chemistry Laboratory is currently on a semi-holiday, with most researchers having gone home for the Chinese New Year. Only doctoral student Cao Fan is staying at his post to clean.

The Active compound from the LPJK1 project have been sent to the Tongzhou Animal Experiment Base for animal testing. Twenty-two Active compound were continuously eliminated during the animal testing process, and currently only five remain.

The laboratory was no longer filled with the usual tension and busyness; instead, it appeared peaceful and serene.

If Academician Nelson and his group had asked to visit the lab two months ago, Shen Qi really wouldn't have agreed.

Now, feel free to visit anytime.

Academician Nelson looked around and said, "Professor Shen, we saw a report in the patent journal about the twenty-two Macrocyclic Compounds synthesized by your laboratory. We were very excited, so we immediately flew to China to have an in-depth exchange with you."

When applying for a compound patent, a general synthetic route is usually required, but patent applicants often do not provide a complete synthetic route in their patent applications.

The LPJK1 project at Shen Qi Research Center has applied for patents for 22 compounds, but like most patent inventors, they have not provided complete synthetic routes.

The LPJK1 project has innovated some important chemical methods in the preparation of Active compound.

The 17 eliminated compounds caused some side effects in animals, but these 17 compounds, along with the remaining 5, are stable in terms of chemical structure and properties.

All twenty-two compounds are Eight-membered heterocyclic compound, which are Macrocyclic Compounds.

Macrocyclic Compounds are typically unstable; they can exist during chemical reactions, but it is difficult to obtain stable final products. Due to the instability of Macrocyclic Compounds, very few organic reactions involving Macrocyclic Compounds have been developed.

This is precisely the main purpose of Academician Nelson and his delegation's visit. "We all know that five-membered and six-membered rings are the most stable, and most chemically synthesized drugs also have five-membered and six-membered ring structures. When mentioning the HIV drug Darunavir, medicinal chemists naturally think of the Patrono-Buchi reaction, or the Aldol reaction, which plays a key role in another synthetic pathway."

"Hmm." Shen Qi nodded, expressing his strong agreement.

Academician Nelson continued, "In developing the prostate drug Sutent, Pfizer Inc. designed many synthetic routes, each with a different core reaction. Ultimately, Pfizer Inc. chose the route centered on the Wittig reaction because this route had the cheapest raw materials. The synthesis of five-membered and six-membered ring drugs has formed a very complete chemical synthesis system, and various named reactions have been developed. However, the synthetic routes and core reactions involved in eight-membered ring drugs are almost impossible to find."

Shen Qi: "Yes, that's right."

Compared to Shen Qi's composure, Academician Nelson became increasingly excited as he spoke, "Your chemical drug research and development team seems to have come up with a new approach. You've obtained twenty-two stable eight-membered heterocyclic Active compound using a newly developed rearrangement reaction as the core! I'd like to know if there are universal rules for synthesizing stable eight-membered ring compounds, or even larger ring compounds, using novel rearrangement reactions as the core? Or, could you share the complete synthetic routes for these twenty-two Macrocyclic Compounds, as well as the entire theoretical system supporting these synthetic routes?"

"Professor Shen, isn't the synthetic route in your patent report far too simplistic? Since you've already applied for a patent, could you perhaps give us a sneak peek and show us the more complete research results? Or, could you publish your latest research findings on Macrocyclic Compounds in a professional academic journal as soon as possible? Oh, Professor Shen, in my opinion, your research results are comparable to 'the discovery and development of the Diels-Alder reaction's and 'the development of the Olefin Metathesis in organic synthesis.'"

Academician Nelson spoke eloquently and passionately, while Shen Qi smiled noncommittally.

Cao Fan, an observer, was overwhelmed with excitement. Holy crap? They discovered and developed the Diels-Alder reaction, and the Olefin Metathesis in organic synthesis... These research achievements are all Nobel Chemistry Prize!

But thinking about it, it's not that surprising. It's just routine for Director Shen to achieve something of Nobel Prize caliber.

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