I Like Eating More Than Anything
The call connected.
"Mom, it's me, Nofi."
"Hmm, Nophie is such a good girl."
"Mom, are you doing well in the hospital?"
"Don't worry, my little Nofi, Mommy's doing great."
"Mom, is the signal good at the hospital?"
"It's fine, I..."
Shen Qi suddenly interrupted, "Honey, get to the point. Professor Qu is coming to see you soon."
"Okay, Nophie, Mommy's just having a routine checkup, everything's fine. You have to listen to Daddy at home, okay?"
"Uh-huh!"
"Nofi, let Daddy take you to buy a new red dress, red shoes, and a red hair clip, then you can wear them and Daddy can take a picture and send it to Mommy, okay?"
Okay.
"You're so great, baby! Mommy loves you!"
"Nofi loves her mother too."
"Mua~"
"Mua~"
"Goodbye, Nofi."
"Bye-bye, Mom."
After the mother and daughter ended the call, Shen Qi said to Nuofei, "Is your mother alright? She's perfectly fine."
"Yes, I hope Mom comes home soon." Shen Nuo Fei felt a little relieved. During the phone call just now, she felt that her mother seemed quite normal.
Cluck~
The cries of hunger rang out.
Nophie patted her stomach and said, "Oh, I'm so hungry."
Shen Qi patted his daughter's head. "Do you want to finish your lunch at kindergarten, or would you like to go out to eat with Daddy?"
Nofino pouted. "Only children make choices."
"Does this big kid want to eat two lunches in a row?"
"I love eating the most!"
"Okay, okay, let's eat!"
A daughter is her father's lover from a past life; it seems that getting a daughter to eat still requires the father's personal intervention.
Yanjing University People's Hospital.
Ou Ye's actual situation was not as wonderful as she portrayed on the phone.
After taking Triazatrisiloxanes for two weeks, Ou Ye experienced symptoms such as loss of appetite and drowsiness.
These are all normal clinical drug reactions, Ou Ye forced herself to persevere.
Before being admitted to the hospital, Ou Ye already ate very little for each of her three meals a day.
After being admitted to the hospital for clinical trials, Ou Ye ate even less.
If a person eats little, their complexion and overall appearance will naturally suffer.
Ou Ye is nearly 1.7 meters tall, but now she only weighs a little over 70 kilograms.
Shen Nuo Fei, a petite girl who is less than 1.2 meters tall, weighs over 50 kilograms.
One can imagine how thin Ou Ye was.
She didn't want her daughter to see her looking so pale and disfigured.
Whether it's a mother or a father, they always want to present their most handsome, beautiful, dashing, and triumphant appearance to their children.
Ou Ye turned on her phone's camera and pointed it at her face.
On the screen, Ou Ye looked pale and thin. Her once-proud, long, straight black hair, which she was most proud of, was now dry and dull.
"I look so ugly..." Ou Ye murmured, unable to bear it any longer, and turned off the camera.
A woman loses her beauty, her vitality, and her health.
Will her husband remain faithful to the marriage?
Let's make a rather mundane hypothetical scenario: If a woman who is frail and sickly hasn't had sexual relations with her energetic, middle-aged husband for a long time, will he have an affair, either physically or emotionally?
Maybe, yes...
It is said that "there are no filial sons at the bedside of a chronically ill patient."
So, will there be a loyal husband by the bedside of a long-term sick person?
Maybe so...
An ellipsis represents uncertainty.
Ou Ye wasn't sure; she could only try to think positively.
Medicine.
You need to take your medicine.
I must get better as soon as possible.
For the children, for my husband, for this family, and for myself.
Medicine.
Take more medicine.
Miracles happen with great effort.
However, medicine should not be taken indiscriminately or in excessive amounts.
In Phase I Clinical Trial, tolerability testing follows strict dosage standards.
The minimum effective dose (MRSD) for humans is usually calculated by taking the NOAEL of the optimal animal and then dividing it by the safety factor.
Several groups were set up from the minimum starting dose to the maximum dose, with at least five dose groups: minimum, lower, medium, higher, and maximum. Each subject was only allowed to receive one dose in the trial.
Ou Ye was placed in the lowest dose group, a decision made after careful consideration by the research physicians and Shen Qi.
Every medicine has some degree of toxicity. The more medicine you take and the higher the dosage, the stronger the toxicological effects.
Phase I clinical trials primarily test the safety of new drugs and the dosage that subjects can tolerate.
Regardless of how much or how little you eat, there are usually some adverse reactions.
If severe adverse reactions such as death, life-threatening situations, organ failure, disability, or birth defects occur, the new drug will be discontinued.
Loss of appetite, vomiting, and drowsiness were considered acceptable adverse reactions by the research team in this clinical trial.
Ou Ye experienced acceptable adverse reactions; she felt somewhat uncomfortable, but it was within the normal range.
At that moment, the ward door opened, Professor Qu, the attending physician, walked in.
Lying in bed, Ou Ye struggled to sit up, Professor Qu quickly stopped her, saying, "Professor Ou, you can just lie there."
After saying that, Professor Qu adjusted the tilt angle of the hospital bed backrest so that Ou Ye could communicate with him in a comfortable position.
"Thank you for your trouble, Professor Qu." Ou Ye forced a smile, which looked almost like she wasn't smiling at all.
"No trouble at all. You are the patient, and I am the doctor. It's only right that I serve you. Besides, Professor Shen is my friend, and you are my friend too. It's only right that I serve my friend." Professor Qu swiped his tablet and said, "You've been taking the medication for two weeks now, and no serious adverse reactions have been observed. Your hemoglobin concentration, hematocrit, protein saturation, and CRP levels are all normal. In other words, it seems that this dosage of the new drug is currently safe for you."
"Professor Ou, you're in the lowest dose group. The lowest dose group will be the first to undergo tolerability testing. In another week, your lowest dose group's tolerability testing will be completed. If the lowest dose group is proven to be safe at that time, then Professor Ou can go home to rest first, and then come back to our hospital for the pharmacokinetic/pharmacodynamic testing in a while. Actually, it's nothing serious. As your research physician and your friend, I just came to chat with you and see if you need anything."
Professor Qu spoke to Ou Ye in a relatively relaxed tone, which made Ou Ye feel safer.
"Professor Qu, when I conduct pharmacokinetic/pharmacodynamic studies, is it possible to increase the dosage?" Ou Ye asked.
Professor Qu shook his head and said, "No, no, we can't do that. We must strictly adhere to clinical trial standards, firstly for the patient's sake, and secondly for better scientific research. Xiao Ou, I understand your eagerness to recover, but let me tell you again, the main purpose of Phase I clinical trials is to study the safety of new drugs. Of course, efficacy trials will also be conducted. Throughout the history of clinical medicine, patients who are completely cured or whose conditions are greatly alleviated in Phase I Clinical Trial of new drugs are extremely rare. Even if you take the highest dose of the new drug, it will be difficult to achieve the desired therapeutic effect. Unless a miracle occurs."
"A miracle... a miracle..." Ou Ye murmured to herself. She remembered a line from a movie. "What's the difference between a person without dreams and a salted fish?"