Flashy and Over-the-Top

"Qi, when you come to the hospital, please bring me something." Ou Ye called Shen Qi.

While reviewing documents in his office, Shen Qi said, "Okay, what should I bring?"

Ou Ye: "Gauss Notebooks, Volume 15."

"Huh? You want to look at this volume of Gauss's Notebooks?" Shen Qi was somewhat surprised. The document in his hand was the Phillips- Klein edition of Gauss's Notebooks, Volume 15.

There are 20 volumes of Gauss's handwritten German notebooks that still exist today, all kept in German academic institutions and not for sale. Even Gauss's portrait was printed on German marks that circulated from 1989 to 2001. This shows the great respect Germans have for scientists, whereas other countries' currencies often feature the portraits of kings, queens, or presidents.

Gauss was the founder of the Göttingen School, and Phillips- Klein was a successor of the Gauss -Göttingen School.

This Phillips Klein was the same Klein who was driven mad by his best friend Poincare.

After going mad, Phillips- Klein lost his fighting spirit in solving mathematical problems. In his later years, he focused on writing the History of Mathematics and translated Gauss's 20 notebooks into English, French, Latin and other languages.

Phillips- Klein's handwritten translation of Gauss's notes in English changed hands several times before finally being collected by the Princeton Institute for Advanced Study.

When Shen Qi returned to China from the United States, he brought back Phillips- Klein's English-language Gauss Notebooks, volumes 15-18.

The Germans will not hand over Gauss's original notes in any form, and Klein's version of Gauss's notes has become an antique today.

In fact, Gauss's Notebooks were published a long time ago and translated into various languages by a publishing group for global sales.

However, mathematicians with status, position, some spare money, and a sense of passion are more willing to collect manuscripts.

Shen Qi either gave away his own manuscripts or exchanged them with other collectors.

The English versions Klein Gauss's Notebooks, volumes 15-18, were the ones Shen Qi exchanged for.

Manuscripts and artifacts from over a hundred years ago should not be handled frequently, otherwise they are easily damaged.

Shen Qi only consults the manuscripts of various scientists throughout history during crucial final moments.

He, his wife, and many top mathematicians believe that manuscripts and printed publications not only differ in terms of prestige, but also carry an unproven yet subtly present spiritual imprint.

"OK, I'll bring you the Gauss notes later. Is there anything else you need?"

"Sanitary napkins."

"Okay, wait for me, see you in twenty minutes."

Ou Ye's needs are extremely simple: academic and physiological.

As requested, Shen Qi brought Gauss's notes and sanitary napkins to Ou Ye's ward.

"So, honey, you're planning to start with the Gaussian quadratic field and then look at rank greater than or equal to 2?"

"Hmm, I think it's feasible. Qi, what do you think?"

"I think it's feasible too, let's do it that way."

Shen Qi suddenly felt a mix of emotions.

Ou Ye couldn't find any mathematical inspiration at home and even fainted.

Once hospitalized, Ou Ye seemed to enter a higher academic realm.

Shortly after Shen Qi left the hospital, some new reports emerged from the international chemistry community.

A research team at the University of California, UC Berkeley, says they have successfully synthesized a Macrocyclic Compounds with 20 chiral centers in the laboratory, with 2 to the power of 20 isomers.

"So intense?"

This was Shen Qi's first reaction upon seeing the report.

The UC Berkeley research team stated in their report, "Referring to the research findings on Macrocyclic Compounds from Shen Qi Team at Yenching University, we have synthesized Macrocyclic Compounds with the most chiral centers to date. The applications of this Macrocyclic Compounds still require further investigation, but we have achieved historic progress in the structure of this new compound."

A research team from the University of Tokyo announced that they have synthesized a novel Macrocyclic Compounds with an extremely complex structure in the laboratory. This new compound has a chemical structure similar to that of Anemonia Toxin, but differs in that it has a macrocyclic structure with eight or more members at key sites.

The research team from the University of Tokyo also thanked Shen Qi Team for providing the Macrocyclic Compounds theory a few months ago. They named the new compound "Turritopsis dohrnii hormone" and said that this new compound helps to reveal some mysterious questions about nature.

Research teams from Germany, the UK, and Australia have also reported their latest research progress on Macrocyclic Compounds. Through experiments, they have demonstrated that the theory of Macrocyclic Compounds and novel rearrangement reactions proposed by Shen Qi Team is very reliable.

"This... this is getting out of control."

Shen Qi didn't know whether to be happy or worried.

He proposed the theory of Macrocyclic Compounds, and after its introduction, chemists from various countries derived all sorts of fancy new products from it.

It is currently difficult to determine the potential practical impact of these fancy new compounds.

Shen Qi's intuition told him that the emergence of a large number of new Macrocyclic Compounds was a double-edged sword; if used properly, it could benefit mankind, but if misused, it could destroy the world.

System: "Host has completed the task of advancing to level 14 in Chemistry. Level up!"

Requirements for promotion to level 15 in Chemistry:

1. 60 million academic points;

2. Using chemical methods to reveal a mystery.

Regardless, advancing to level 14 in Chemistry is something to be happy about.

Advancing to level 14 in mathematics and physics is targeted at specific goals.

The system requires Shen Qi solve some specific mathematical and physical problems in order to advance to level 15.

Condition 2 for advancing to level 15 in Chemistry is open-ended and requires Shen Qi to explore it himself.

Yanjing University People's Hospital.

Tolerance testing of Triazatrisiloxanes was completed.

The research team led by Professor Qu used statistical methods to process clinical data such as the number of individuals, mean, median, standard deviation, coefficient of variation, geometric mean, and geometric standard deviation.

Based on clinical observations and data analysis, Professor Qu's team believes that Triazatrisiloxanes has passed the tolerability test, and all subjects will now proceed to the pharmacokinetics/pharmacodynamics test.

Many studies have reported that the success rate of new drugs in clinical trials is around 10%, meaning that only one out of ten candidate drugs can eventually be marketed.

Studies have shown that the main reasons for clinical development failure are efficacy (66%) and safety (21%).

The most basic requirement for a drug is that it has good safety, will not kill people, and will not have serious side effects.

The core indicator that determines whether a new drug can be marketed is its effectiveness, that is, the effect of the drug in treating patients.

To prevent expensive drugs from failing in Phase I Clinical Trial, proof-of-concept studies using efficacy as an indicator must be conducted in Phase I Clinical Trial. This allows drugs that are unlikely to be successfully developed to be phased out early, thus avoiding wasted money.

Based on the above clinical trial approach, Ou Ye was finally able to take Triazatrisiloxanes again.