Arc 4The Challenge at the Valley
Takenaka Kaguya left Kirigakure after its succession struggle turned violent, then renewed his feud with Madara Uchiha and traveled to Konoha. There he challenged Hashirama Senju, and their fierce battle left Madara and Tobirama reassessing Takenaka’s strength.
- Takenaka Kaguya learned that Byakuren would not support his bid to become Second Mizukage, and Genji later told him Hozuki Gengetsu had secured the clans' backing.
- Takenaka Kaguya decided to leave Kirigakure, but Motosawa Kaguya and the Kaguya Clan Jonin blocked him at the docks, where he killed them after they attacked.
- Hozuki Gengetsu denied ordering the Kaguya Clan's attack, and Takenaka Kaguya gave him his Kirigakure forehead protector and warned that he would return if Gengetsu failed as Mizukage.
- Takenaka Kaguya encountered Madara Uchiha on his way to Konoha, refused his offer to join his plan, and fought him until Madara escaped underground as Hashirama Senju arrived.
- Hashirama Senju brought Takenaka Kaguya to Konoha, where Mito Uzumaki welcomed him and he said he would stay in Uzushiogakure while considering Lord Ashina's offer to lead the village.
- Takenaka Kaguya challenged Hashirama Senju at the Valley of the End, and the two escalated their fight as Hashirama summoned the True Several Thousand Hands.
- Takenaka Kaguya dodged the statue's giant hands and shattered its leg with a Haki-coated punch before teleporting to Hashirama Senju and exchanging blows.
- Madara Uchiha recognized Takenaka Kaguya as a serious obstacle, while Tobirama Senju abandoned his confidence that he could defeat him.