Ōtsutsuki Isshiki was an alien, yes, but so was Kaguya Otsutsuki.
Was the Uzumaki Clan's constitution not strong enough? Or was it because he had created them himself...
Wait. Had Kaguya Otsutsuki really given birth to Hagoromo Otsutsuki and Hamura Otsutsuki with a human?
Could Ōtsutsuki Isshiki have been the father of Hagoromo Otsutsuki and Hamura Otsutsuki?
No, that still didn't add up. Even if it explained Kaguya Otsutsuki's generation, how had Hagoromo Otsutsuki had children with people of the Ninja World?
Yin–Yang Release...
That was the only explanation. Perhaps Hagoromo Otsutsuki and Hamura Otsutsuki had been lives created through Yin–Yang Release.
Or perhaps Indra and Asura had been. Either way, it would explain how all this worked. (The protagonist did not know Kaguya Otsutsuki's backstory in the manga.)
"Is there a way to solve this problem?"
After thinking it over, Uchiha Ensei put the question to Tsunade.
As the greatest medical expert in the Ninja World, Tsunade had the most comprehensive understanding of the human body. Even Orochimaru sought her help when he encountered a problem with the body that he could not solve.
So Uchiha Ensei had made the same choice.
By then, Tsunade's initial shock and disgust had turned to curiosity.
Tsunade certainly disliked experiments that desecrated life.
But an experiment Uchiha Ensei himself was conducting was clearly different from the usual human experiments.
Besides, Tobirama Senju had conducted human experiments too. As long as no comrades were harmed, it was not such a serious issue.
"This is... the Uzumaki Clan's Kekkei Genkai combined with some unknown, highly invasive cells."
"Your method is sound, but you overlooked the difference in their levels of life."
"An experiment like this can't succeed."
Before long, Tsunade delivered her definitive conclusion.
It was no different from Uchiha Ensei's own guess. It,