Arc 6The Fall of Aizen
Tokoyo Misao and the Soul Reapers faced Aizen’s betrayal as Ichigo and his companions entered Soul Society, while Isshin’s execution and the fate of the three worlds came under threat. Aizen escaped to Hueco Mundo, Gin stayed behind with Rangiku, and Misao’s own allegiance remained uncertain.
- Kisuke Urahara revealed that Senna was a Shinenju, and Tokoyo Misao protected her from armored men before escorting her to Soul Society.
- Tokoyo Misao confronted Ganryū Ryōdōji, who planned to use Senna to make the Valley of Screams Space collapse, then killed Ganryū and his companions and took Senna to Soul Society.
- Tokoyo Misao fought Unohana and Kenpachi Zaraki, helped Uryū Ishida recover Quincy power, and later battled Zaraki in the Valley of Screams Space as Yachiru Kusajishi fought Sasakibe.
- Ichigo Kurosaki and his companions entered Soul Society, where Orihime Inoue fought her way toward the Tenth Division and Aizen deceived her into helping him remove the Hōgyoku from Isshin.
- Aizen framed Tokoyo Misao for the Central 46’s murder and revealed his betrayal at Isshin’s execution, defeating several captains as Ichigo and Isshin confronted him.
- Ichigo exposed Aizen’s use of Kyōka Suigetsu, while Tokoyo Misao faced Aizen and sent Ichigo to protect Isshin.
- Tokoyo Misao tore open Gin Ichimaru’s Negación and brought him back to Soul Society, while Aizen escaped to Hueco Mundo and Gin reunited with Rangiku Matsumoto.