The Rapid Growth of Shen Nuo Fei

Ou Ye's fellow patient crawled on the ground like a reptile, shouting, "What can you do to me? What can you do to me?"

Professor Qu shouted, "He Yuankai, that's enough!"

Suddenly, the patient grabbed Professor Qu's leg and burst into tears, crying, "Professor Qu, I'm a patient! You have to explain the situation to them. I'm seriously ill, they can't take me away! I want to stay in the hospital, I want treatment!"

Professor Qu waved his hand and said, "Take him away!"

As the mentally unstable patient was taken away, Shen Qi became alert, while Ou Ye wore a look of disgust.

"Old Qu, what's the situation with He Yuankai? I remember he was a clinical trial participant in Triazatrisiloxanes, right? Is he having mental problems? It shouldn't be a side effect of the drug, should it?" Shen Qi was a little nervous. Triazatrisiloxanes had finally made it to Phase I clinical trials. If he developed mental side effects, it would be all over!

"He's faking it," Professor Qu said, shaking his head. "This man is a university professor. I just received the news that he's under investigation for embezzling and misappropriating project funds."

Shen Qi let out a long sigh, but was also filled with righteous indignation. "Damn it! How could they have recruited such a morally corrupt person into the testing group?"

Looking up at the magnificent sunset at a 45-degree angle, Lao Qu said solemnly, "In a doctor's eyes, there is only the distinction between patients and non-patients."

Ou Ye said indignantly, "That guy surnamed He is a real scoundrel! He's under investigation for embezzling public funds, and he's slept with so many female students, doesn't anyone care?"

Shen Qi said, "It's not uncommon in some universities for students to beg their teachers to let them off the hook when they can't write their papers or fail their exams. A few years ago, I set a Mathematical Analysis exam, and 80% of the math department students failed. Some of the failing students begged me to give them extra points... There's no way to manage that; the teachers didn't force the students, they just came to me willingly..."

Ou Ye pinched Shen Qi's waist hard. "Shen Qi, I'll allow you to organize your thoughts and say it again."

Shen Qi said sternly, "Yes, I must take charge! Other places may not be under my jurisdiction, but at Yenching University, I must take charge. After that, the School of Mathematics never invited me to set exam papers for mathematics students again; I haven't set any papers for several years now."

Ou Ye asked, "I remember that tragic incident of failing grades. In the end, it seems that only 30% of the students failed, and you let the remaining 50% go?"

Shen Qi: "I added a few points to all the students who actually scored above 50. It's not easy for students to come to Yenching University, and the questions I set that time were indeed very difficult."

Ou Ye became alert. "Did you sleep with the female students?"

Shen Qi waved his hands repeatedly. "No, no, no! All the students who come to me for help are male. All the doctoral students I supervise are male too."

"Oh."

"Old Qu, let's talk about something serious. Let's go to your office." Shen Qi told Ou Ye to go back to the ward first, while he and Professor Qu discussed medical issues.

After the tolerability test is completed in Phase I clinical trials for a new drug, the next step is pharmacokinetic and pharmacodynamic tests.

Triazatrisiloxanes has now progressed to the pharmacokinetic and pharmacodynamic (PD) stages. At this stage, the research team uses PK to study the absorption, distribution, metabolism, excretion, and time process of the drug in subjects, and uses PD to study the time process of drug action.

Through PK/PD and related mathematical methods, combined with clinical observation, preliminary results have been obtained from the Phase I clinical trials of Triazatrisiloxanes.

Including Ou Ye, there were a total of 60 Phase I clinical trial participants.

As Ou Ye's husband, Shen Qi was most concerned about the tolerance and pharmacokinetics/efficacy of Triazatrisiloxanes in Ou Ye.

As the developer of Triazatrisiloxanes, Shen Qi also needs to pay close attention to the clinical performance of these 60 subjects, including previous animal experimental data and subsequent Phase II and Phase I Clinical Trial.

Whether a new drug can be marketed depends on its safety and efficacy in the vast majority of target subjects.

Shen Qi certainly hoped that Triazatrisiloxanes could eventually be marketed, and his focus gradually shifted to other subjects.

Professor Qu showed Shen Qi a pharmacokinetic/pharmacodynamic model based on 60 subjects. It is currently a work in progress and needs to be supplemented with more data, but some trends can be seen.

"Tmax and Cmax are obtained through actual measurements, and AUC0~t is obtained through the trapezoidal rule. We use λ2 to calculate the estimated values of t1/2 and AUCt~inf. This is a non-compartmental model, which is the main pharmacokinetic calculation method in pharmacokinetic, bioequivalence, and bioavailability studies, and is also the legally required calculation method in new drug applications."

"However, parameters obtained from non-compartmental models are sometimes difficult to use for establishing PK prediction models and conducting PK/PD association analysis. Therefore, in this clinical trial, we also used a compartmental model and conducted rigorous Mathematical Analysis. Director Shen, look, this is sample 6. After the drug enters the body of sample 6, it is distributed to the target site and produces a pharmacological effect after binding to the target site, thereby causing physiological and pathological changes, which in turn bring about clinical therapeutic effects."

"Sample 6's data is very good, who is this person?"

"Sample 6 is your wife."

"Oh, not bad, not bad at all, pretty good. But with a sample size of 27, it seems less than ideal."

"Sample 27 is He Yuankai, the university teacher who was just pretending to be crazy."

"Let's look at the overall model analysis."

"The overall model isn't finished yet, but that's alright. Let's look at the process data. Director Shen, you see, through LC-MS/MS analysis, within our defined range, the relationship between drug concentration and its signal response is described by a weighted linear regression function, or it can be described by a binomial formula..."

"Old Qu, step aside, I'll help you describe it using binomials."

Shen Qi volunteered to take on the task of mathematical model calculation and analysis, and after more than half an hour, he completed the binomial description of the overall model.

Compared to the weighted linear regression function, the binomial description reveals a more detailed relationship between drug concentration and its signal response.

"When Fields Medal winner makes a move, it's definitely different."

The Phase I Clinical Trial of Triazatrisiloxanes is nearing its end. The main task at this stage is data analysis and processing to ultimately produce a written report. Research teams and clinical teams rely on data to support their new drug applications or publish papers, and written reports are used to determine research results.

Shen Qi conveniently provided Professor Qu with a binomial description, which accelerated the data processing progress of the clinical team.

Based on the existing data, considering the maximum, minimum, and average values, Triazatrisiloxanes has a very high chance of passing the Phase I Clinical Trial.

Following the publication of Ou Ye's formal paper on the Strong BSD Conjecture, numerous mathematical teams worldwide have announced that they have begun work on interpreting and verifying the Strong BSD Conjecture.

These mathematics teams include the Clay Mathematics Institute's Bhargava team, Columbia University's Gong Changwei team, the Weizmann Institute of Science's Lyndon Strauss team, Oxford University's Hadamard team, Shuimu University's Su Wenxie team, and UCLA's Terence Tao team...

The explanation and verification of the strong BSD Conjecture seem to have become an academic competition.

Formal academic institutions and renowned mathematicians across Europe, America, and Asia have taken action, and Folk Scientist around the world are not to be outdone.

A retired math teacher from Ou Ye's high school alma mater declared on a high-traffic video website, "I have verified that Ou Ye's <Strong BSD Conjecture> is true. No need to thank me, it's what I should do."

Actions speak louder than words, so the retired math teacher showed several verification manuscripts in the video, which looked very professional.

At the end of the video, a retired math teacher said, "Come to Little Genius Math Class, and we'll help your child win gold medals in the International Mathematical Olympiad and achieve a 98% success rate in getting into top universities!"

"So it was just an advertisement!" netizens exclaimed.

Some netizens commented, "These days, even advertising training courses requires some skill. At least this math teacher's verification manuscript looks very professional."

Hidden talents abound among the common people; there might even be unparalleled masters like the Sweeping Monk.

Without a doubt, Teacher Liu, the instructor of the Second Experimental Primary School Pomegranate Math Class, is a master.

Teacher Liu is a mathematics PhD graduate from Fudan University. He is an officer of the Chinese Mathematical Society and previously served as the algebra coach for the Chinese Mathematical Olympiad National Team.

Teacher Liu is extremely experienced in mathematics competitions. He is a decorated coach who has trained many IMO gold medalists, including Shen Qi and Zhou Yu'an, and helped the Chinese Mathematical Olympiad team win the IMO team championship for five consecutive years.

A PhD in mathematics from a prestigious university, an officer of the Chinese Mathematical Society, a decorated coach of the national math Olympic Math national team... With such an illustrious background, why would Teacher Liu willingly serve as an instructor for an elite math class at a primary school?

There must be a shocking secret hidden within.

"Shen Nuo Fei, can you solve this equation?" Teacher Liu tapped the blackboard in the small classroom. He was not a tenured teacher at Second Experimental Primary School; he was a mentor teacher hired by Second Experimental Primary School at a high salary.

There was only one student in the small classroom; she was Shen Nuo Fei.

As arranged by the Second Primary School Mathematics Teaching and Research Group, when Shen Nuo Fei, a student in Class 1(2), attends math class in Class 1(2), she will go to the small classroom to receive careful guidance from Teacher Liu of the Pomegranate Math Class.

The equation on the blackboard is: 12 - 3(9 - x) = 5(x - 4) - 7(7 - x)

This linear equation problem is part of the fifth-grade curriculum, and it's definitely beyond the scope of most first-grade students.

But for Shen Nuo Fei, things beyond the curriculum were normal.

A week ago, this question was beyond the syllabus.

Now, under Teacher Liu's tutelage, Shen Nuo Fei has mastered the core techniques of solving linear equations in one variable.

Shen Nuo Fei nodded and said, "Teacher Liu, I know how to do this question."

Teacher Liu handed half a piece of chalk to Shen Nuo Fei: "Come on, write down the steps to solve the equation on the blackboard. If you give the correct answer, then we will immediately move on to the teaching of multivariable equations."