Hashirama Senju and Tobirama Senju were dead, so neither could serve as a vessel.
Ōtsutsuki Isshiki did not know Sasuke Uchiha, but he could sense the man's strength. Sasuke wielded the Power of All Creation. Taking over his body would be all but impossible.
Isshiki soon turned his gaze to Uchiha Mikoto, Kushina Uzumaki, and Hyuga Rinka. One was an ordinary Uchiha, one was the Nine-Tails Jinchuriki, and the last possessed the Byakugan and appeared to be a descendant of Hamura Otsutsuki.
Isshiki was far more wary of Hagoromo Otsutsuki than of Hamura Otsutsuki.
So what if the vessel was a woman?
To Isshiki, being male or female hardly mattered. All that mattered was whether the vessel would benefit his strength.
He could clearly sense that Rinka's bloodline had undergone Atavism. Its purity was nearly on par with Asura's and Indra's back then.
If he could implant a Kāma in Rinka, he could recover his strength to the greatest possible extent.
His only worries were whether Uchiha Yi would notice something amiss, and whether Hamura and Hagoromo would discover him and move against him.
But at this point, even if he could defeat Yi, he had to make a choice. He had to implant a Kāma in one of them.
"Those who kill must be prepared to die by another's hand. Ōtsutsuki Isshiki, your fate was decided long ago.
"When your clan ravaged planet after planet, you took on the curses of countless lives. There is only one end for you." Terrifying Chakra gathered in Yi's hand, growing so dense it became tangible. It erupted, then Yi compressed it again and again. Golden light flashed into existence, forming a long sword that slashed toward Isshiki.
Golden Wheel Reincarnation Explosion!
It was the first time Yi had used a Tenseigan eye