Arc 49Karma and the Six Tomoe Rinnegan
Shinji captured Ōtsutsuki Toneri, recruited him to guard the Giant Tenseigan, and prepared for Ōtsutsuki Isshiki’s return while developing Karma and strengthening his allies. The arc leaves Shinji inside Nameless’s inner world, where he finds a girl imprisoned in a cell.
- Jigen attacked Nagato after Nagato refused to join forces against 'A', implanted Karma in him, and took him to his laboratory while Konan escaped.
- Shinji learned that Ōtsutsuki Isshiki was active as Jigen and led Karin, Nameless, Sasuke, Haku, Neji, and Kimimaro to the moon, where they defeated and captured Ōtsutsuki Toneri.
- Shinji revealed the truth about the Otsutsuki Branch Family to Ōtsutsuki Toneri, then made him guard the Giant Tenseigan under the code name Z and transferred his soul into a Superalloy Puppet.
- Shinji arranged for Haku to train in Senjutsu at Ryūchi Cave and agreed with Orochimaru to feign cooperation with Isshiki while preparing to trap him.
- Shinji removed Sasuke’s Cursed Seal and transplanted First Hokage cells into him, then developed a Karma prototype by imprinting his digitized personality into it.
- Nameless used Yachihoko to help Karin awaken a Six Tomoe Rinnegan, and Karin revealed that her Tamatsukuri Spear could exchange states between herself and a target.
- Ōtsutsuki Isshiki reincarnated in Nagato’s body and ordered Amado to activate sealed artificial humans, while Nameless began her own Rinnegan awakening attempt.
- Shinji entered Nameless’s inner world through Naobi and found a small girl locked in a dark underground cell.