Naruto's Signature Move
Unable to untangle the branches, Hiruzen Sarutobi summoned his ally, the Monkey King Enma, using a summoning technique, transforming him into Adamantine Staff to sever the binding branches. He then revealed his true form to his former master—the face of a young, beautiful female ninja hidden beneath a mask—to prove his Living Corpse Reincarnation was successful and that he had been using her body for many years (at this point, Orochimaru, though his soul remained unchanged, was physically a woman, and his voice when not wearing the mask was that of a woman). The Third Naruto, seeing his former disciple had gone mad, decided to exterminate him.
When the two initially clashed Reaper Death Seal Naruto Seal, they were evenly matched. Although the Third Naruto was known as the "Strongest Naruto," his strength had declined due to old age and physical weakness, and he was unable to withstand the attack. He had no choice but to use the Reaper Death Nine-Tails, the same ninjutsu the Fourth Hokage used to Reaper Death Seal the Nine- Orochimaru. The Third Naruto used two Shadow Clones to seal the First and Second Naruto, while his own body sealed Naruto. However, during the sealing process, Orochimaru manipulated the Kusanagi Sword, severely injuring the Third Naruto. Ultimately, the Third Hokage was unable to completely seal Orochimaru, only losing his hands and being unable to use ninjutsu.
After his hands were crippled, he lost the ability to use ninjutsu (since most ninjutsu require hand seals and chakra manipulation to execute), and had no choice but to lead the Sound Ninja in retreat. The Sand Ninja later learned that the real Wind Shadow had been assassinated by Orochimaru, and thus renewed their peace treaty with Konoha. Orochimaru's "Konoha Crush Plan" ultimately ended in failure.
The Legendary Sannin Orochimaru: Orochimaru, seeking treatment for his hands, along with his subordinate Kabuto, went to Tanzaku Town to consult Tsunade, the legendary healer of the Legendary Sannin. Due to Tsunade's adamant stance, Orochimaru offered to revive Tsunade deceased brother and lover (the forbidden Edo Tensei technique) as a condition, setting a seven-day deadline. Seven days later, the two sides negotiated again, but Tsunade refused Orochimaru's offer. Seeing this, Orochimaru and Kabuto decided to subdue Tsunade and force her to treat them. Meanwhile, Jiraiya and Naruto arrived at the scene.
Orochimaru initially gained the upper hand by exploiting Tsunade's fear of blood, but Tsunade was later inspired by Naruto to overcome her fear of blood and used Creation Rebirth, leading to a great battle between the Legendary Sannin.
Before the Legendary Sannin could fight, Naruto used the newly learned Rasengan on Kabuto and successfully injured him, but he also collapsed due to exhaustion. At this time, Orochimaru and Jiraiya were fighting fiercely. Orochimaru wanted to take this opportunity to finish off Naruto, but his sword was blocked by Tsunade, and Orochimaru failed to succeed.
Orochimaru and Manda were defeated, and Orochimaru and Kabuto retreated. Later, unable to bear the pain of his original woman's body having his hands sealed, Orochimaru ordered the Sound Four to persuade Sasuke to join the Sound Village. Before Sasuke arrived, Orochimaru had to abandon the beautiful woman's body, which was now unable to use its hands (because reincarnation damages the soul, it's not easy to reincarnate while the vessel is still usable). He temporarily used the body of the ninja Gen'yūmaru for soul reincarnation. Although the Sound Four and Kimimaro, who possessed Kekkei Genkai, later died, he successfully brought Sasuke to the Sound Village and actively trained him, intending to use Sasuke as his next vessel.
Three years after the Naruto: Shippuden, Yamato, the captain of Konoha's new Team 7, receives information from Sasori of Akatsuki that his spy, sent to meet Orochimaru at the Tenchi Bridge, intends to find clues about Sasuke. To Orochimaru's surprise, Yamato, the test subject Yamato, survives. He then engages in a fierce battle with Naruto transforms into the Four-Tails Fox in a fit of rage (Kabuto calls this a battle between monsters). However, due to his physical limitations, Sai leaves with Kabuto and Danzō, who was sent by Danzo to negotiate.
However, the Orochimaru team didn't give up. They tracked Orochimaru to his lair, found him, and successfully persuaded Sai to rejoin the team. They then split into two groups to speed up the search for Sasuke. On their journey Sai Yamato Naruto's team encountered Orochimaru, Orochimaru fought Naruto again. Naruto then told Sai to go find Sasuke first. Later, Sakura and Yamato arrived to help, and Orochimaru, unwilling to fight, disappeared without a trace. Soon after, Naruto, Sakura, and Sasuke met again, but Sasuke showed no mercy and wanted to kill them all.
At this moment, Orochimaru suddenly appeared and surprisingly stopped Sasuke killing Naruto. Orochimaru believed that they still had value and could kill a few more Akatsuki members for him (because Orochimaru was once a member of Akatsuki, and after defecting from the Akatsuki, he was also hunted down by Akatsuki).
Sasuke understood and abandoned his plan to kill Naruto and the others, disappearing with Orochimaru into the wind.
After the three-year period of the Living Corpse Reincarnation expired, even Kabuto's medicine couldn't save him. Orochimaru believed it was time to use Sasuke's body for Spirit World Reincarnation. Meanwhile, Sasuke felt that Orochimaru had learned everything he needed to learn and was of no use to him, so he preemptively attacked, rushing into Orochimaru's room to assassinate him. Orochimaru was not to be outdone, using the White Snake Possession Technique to transform himself into a gigantic snake with immense power.
Orochimaru intended to use this technique to possess Sasuke's body, but due to his extremely weak state, he was no match for Sasuke's Sharingan and was absorbed by Sasuke, his soul and power completely suppressed. Later, when Sasuke fought his brother Itachi, Orochimaru was released due to exhaustion of chakra. After regaining his power, Orochimaru used the Eight Branches Technique, intending to seize Sasuke's body and fight Itachi. However, he had almost all of his Totsuka Blade sealed by the Totsuka Blade, which he had painstakingly sought, and his life-saving white snake was burned to death by Itachi's Amaterasu.
During the Fourth Shinobi World War Fourth Shinobi World War, Sasuke, Jugo, and Suigetsu Hozuki revived Orochimaru from Anko Mitarashi's Curse Mark, retrieved their chakra and the information Kabuto had gathered during that time from Kabuto, and together with Sasuke, Suigetsu Hozuki, and Jugo, went to find "the one who knows the whole truth."
Afterwards, Orochimaru used the contents of a scroll he had left behind at the Uchiha Clan's Naka Shrine to release his hands, Reaper Death Seal, and the souls of the previous Fourth Hokage Naruto. He then used the White Zetsu possessing Sasuke to perform the Sasuke Edo Tensei, summoning the previous Fourth Hokage Naruto. He himself escaped his dying body in the form of a white snake, took over the body of the White Zetsu containing the First Hokage's cells, and regained his arms.
During his time inside Kabuto, Orochimaru came to a realization: even Kabuto, who had been learning his way of life and meticulously planning everything, had failed. Therefore, he chose to help Sasuke, wanting to witness a life different from his own.
After Sasuke decides to stop Madara Uchiha's plot, Orochimaru and the remaining members of Taka rush to the battlefield to treat the Five Kage. Orochimaru and the Third Naruto team up to fight the God Tree's split forms. The master and apprentice first use Orochimaru's Hidden Shadow Snake Hands to entangle the God Tree's split forms, and then the Third Naruto uses his Ruyi Jingu Bang to break the God Tree. Tsunade sees Jiraiya's grave and feels ashamed. Through everyone's tireless efforts, Obito Uchiha, the Ten-Tails Jinchuriki, is finally defeated.